UV DNA damage results in bulky DNA adducts - these adducts are mostly thymine dimers and 6,4-photoproducts. CENSORSHIP has now reached EXTREME levels across the 'net. Cholesterol-lowering statins are responsible for destroying health, causing Alzheimer's What this all means for statin drugs, which mainstream medicine has ridiculously dubbed 'miracle drugs,' is that their cholesterol inhibiting properties can cause serious health problems down the road. Subscribe now if you want to escape the delusional bubble of false reality being pushed by Google and Facebook. At any given time, most of the genome in an organism is not undergoing transcription; there is a difference in NER efficiency between transcriptionally silent and transcriptionally active regions of the genome. In addition to how to keep prostate healthy naturally stabilizing TFIIH, XPG also has endonuclease activity; it cuts DNA damage on the 3' side while the XPF– ERCC1 heterodimeric protein cuts on the 5' side. Stem cells are essentially blank slates that have ability to turn into a variety of different tissues and, as such, play a big role in the development of a fetus. (NaturalNews) Including high-cholesterol foods as part of a healthy diet may not be the how to repair a damaged liver poor dietary choice we have all been told it is, suggests a new study published in the journal Nature Medicine. Cholesterol, which is commonly dismissed as harmful and something that people should avoid, how to repair a damaged liver actually contributes to producing and maintaining myelin sheaths. The principal difference between TC-NER and how to repair a damaged liver GG-NER is that TC-NER does not require XPC or DDB proteins for distortion recognition in mammalian cells. It turns out that cholesterol actually helps increase production of an important component of the nervous system that facilitates proper nerve cell communication, and prevents the onset of brain diseases such as Parkinson's and Alzheimer's disease. For many types of lesions, NER repairs the transcribed strands of transcriptionally active genes faster than it repairs nontranscribed strands and transcriptionally silent DNA. In this study, researchers mated female mice with transgenic male mice that were tagged with a fluorescent protein that allowed the researchers to trace the flow of the fetus’s stem cells from the mother’s placenta into its heart while they induced cardiac injury to the mother. The information on this site is provided for educational and entertainment purposes only. If you don't join our email list, you may never see our valuable content again via Facebook, Google or YouTube. XPA, XPB, XPC, XPD, XPE, XPF, and XPG all derive from хeroderma pigmentosum and CSA and CSB represent proteins linked to Cockayne syndrome. TFIIH and XPG are first recruited to the site of DNA damage (XPG stabilizes TFIIH). NER can be divided into two subpathways: global genomic NER (GG-NER or GGR) and transcription coupled signs and symptoms of an asthma attack NER (TC-NER or TCR). The truth is how to repair a damaged liver being suffocated. There are 9 major proteins involved in NER in mammalian cells. A popular (but completely citation-free) science meme suggests that a pregnant mother’s fetus can send its own stem cells to its mother to repair damaged organs. Recognition of the damage leads to removal of a short single-stranded DNA segment that contains the lesion. Your use of this website indicates your agreement to these terms and those published here. A 1996 study in Proceedings of the National Academy of Sciences, for example, found that in humans, genetically distinct cells from a male fetus persisted in the mother’s body as long as 27 years after birth. This research, the authors state: Points to the presence of precise signals sensed by cells of fetal origin that enable them to target diseased myocardium specifically and to differentiate into diverse cardiac lineages. The idea with fetomaternal chimerism is that those cells can be transported out of the fetal system and become fully integrated into the mother’s system despite the cells’ distinctly different genetics. Soon, the only way we what are the symptoms of a heart attack will be able to reach you is via email, and Google is sometimes blocking our email delivery to gmail users. Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). The two subpathways differ in how they recognize DNA damage but they share the same process for lesion incision, repair, and ligation. While the wording of the meme is problematic for two reasons (first, the meme’s text generally says ‘baby’, which is incorrect as that term how to repair a damaged liver implies a birth; second the wording implies a conscious decision on the part of the fetus to send its tissues as a heroic gesture), the science behind the claim is actually fairly solid. They found that fetal stem cells directly targeted the damaged cardiac cells and fully integrated themselves into the mother’s heart. Transcription factor II H (TFIIH) is the key enzyme involved in dual excision. Without it, as evidenced by the recent studies, individuals with PMD -- and potentially all individuals -- are at a higher risk of developing cognitive illness and brain degradation. It is these myelin sheaths, which are composed of lipid fats and how to repair a damaged liver proteins, that allow nerves to communicate and send appropriate electrical signals that trigger movement and cognition, and that protect nerves from damage. After we were banned by Google for nearly a week, now Facebook is deliberately blocking the sharing of our stories to further censor our important reporting for human freedom and medical choice. And particularly those with PMD, low-cholesterol diets are almost sure to leave them exceptionally prone to nerve damage. All trademarks, A coordinated censorship attack is being waged against the entire independent media by Google, YouTube and Facebook. Those on the high-cholesterol diet stopped experiencing cognitive decline, while the low-cholesterol mice continued to get worse. The TFIIH subunits of XPD and XPB act as a 5'-3' and 3'-5' helicase, respectively - they help unwind DNA and generate a junction between the double-stranded and single-stranded DNA around the transcription bubble. Inhibition of gap filling DNA synthesis and ligation results in an accumulation of RPA-bound sedDNAs in the cell. TC-NER and GG-NER differ only in the initial steps of DNA damage recognition. A more complete list of proteins involved in NER is found below. Your privacy is protected and you can unsubscribe at any time. By interfering with the liver's natural function of producing cholesterol, statin drugs can actually strip the body of much-needed cholesterol, and cause serious nervous system and cognitive damage. Nucleotide excision repair is more complex in eukaryotes than prokaryotes, but the general principle is similar. Instead TC-NER initiates when RNA polymerase stalls at a lesion in DNA: the blocked RNA polymerase serves as a damage recognition signal, which replaces the need for the distortion recognition properties of the XPC-RAD23B and DDB complexes. Deficiencies in certain proteins leads to disease; protein names are associated with the disease. The study focused specifically on patients with a condition known as Pelizaeus-Merzbacher disease (PMD), in which nerve cells are unable to properly manufacture protective myelin sheaths. The undamaged single-stranded DNA remains and DNA polymerase uses it as a template to synthesize a short complementary sequence. CS proteins (CSA and CSB) bind some types of DNA damage instead of XPC-Rad23B. "This six-week-long cholesterol treatment delayed the decline in motor coordination," wrote the scientists in their report. The dual incision leads to the removal of a ssDNA with a single strand gap of 25~30 nucleotides. Scientists have been aware of fetomaternal microchimerism’s existence (in broad terms) for decades. Enter your email address below to subscribe to our email announcement list (but don't use gmail). A 2015 study published in the journal Circulation Research addressed the issue of fetal stem cells actually healing maternal organs. Although any memes of this nature run the gamut from “nodding acquaintance with truth” to “has never met truth and never will,” this particular one is mostly accurate. Final ligation to complete NER and form a double stranded DNA is carried out by DNA ligase. Additionally, the proteins ERCC1, RPA, RAD23A, RAD23B, and others also participate in nucleotide excision repair. Researchers from the Max Planck Institute of Experimental Medicine in Germany fed a group of mice with PMD a high-cholesterol diet for six weeks, as well as another group of PMD mice a low-cholesterol diet. Most notable is their differentiation into functional cardiomyocytes that are able to beat in syncytium with neighboring cardiomyocytes, thus potentially uncovering an what foods to avoid for gastritis evolutionary mechanism whereby the fetus assists in protecting the mother’s heart during and after pregnancy. The small, excised, damage-containing DNA (sedDNA) oligonucleotides are initially released from the duplex in complex with TFIIH but then dissociate in an ATP-dependent manner and become bound to RPA. Truth Publishing assumes no responsibility for the use or misuse of this material. It is not intended as a substitute for professional advice of any kind.